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Cambridge Centre for Physical Biology

 

September


 

Red blood cell tension protects against severe malaria in the Dantu blood group

Kariuki SN, Marin-Menendez A, Introini V, Ravenhill BJ, Lin YC, Macharia A, Makale J, Tendwa M, Nyamu W, Kotar J, Carrasquilla M, Rowe JA, Rockett K, Kwiatkowski D, Weekes MP, Cicuta P, Williams TN, Rayner JC.

Nature. 2020 Sep 16. doi: 10.1038/s41586-020-2726-6. 

 

Photoacoustics resolves species-specific differences in hemoglobin concentration and oxygenation

Hacker L, Brunker J, Smith ESJ, Quiros-Gonzalez I, Bohndiek SE.

J Biomed Opt. 2020 Sep;25(9). doi: 10.1117/1.JBO.25.9.095002.

 

Fast volumetric fluorescence imaging with multimode fibers

Wen Z, Wang L, Zhang X, Ma Y, Liu X, Kaminski CF, Yang Q.

Opt Lett. 2020 Sep 1;45(17):4931-4934. doi: 10.1364/OL.398177.

 

August


Intracellular pH controls WNT downstream of glycolysis in amniote embryos

Oginuma M, Harima Y, Tarazona OA, Diaz-Cuadros M, Michaut A, Ishitani T, Xiong F, Pourquié O.

Nature. 2020 Aug;584(7819):98-101. doi: 10.1038/s41586-020-2428-0. 

 

A heterogeneous microbial consortium producing short-chain fatty acids from lignocellulose

Shahab RL, Brethauer S, Davey MP, Smith AG, Vignolini S, Luterbacher JS, Studer MH.

Science. 2020 Aug 28;369(6507):eabb1214. doi: 10.1126/science.abb1214.

 

Pathogenetic profiling of COVID-19 and SARS-like viruses

Nain Z, Rana HK, Liò P, Islam SMS, Summers MA, Moni MA.

Brief Bioinform. 2020 Aug 11:bbaa173. doi: 10.1093/bib/bbaa173. 

 

Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics

Oliva MK, Pérez-Moreno JJ, O'Shaughnessy J, Wardill TJ, O'Kane CJ.

Front Neurosci. 2020 Aug 10;14:816. doi: 10.3389/fnins.2020.00816. eCollection 2020

 

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

Flagmeier P, De S, Michaels TCT, Yang X, Dear AJ, Emanuelsson C, Vendruscolo M, Linse S, Klenerman D, Knowles TPJ, Dobson CM.

Nat Struct Mol Biol. 2020 Aug 10. doi: 10.1038/s41594-020-0471-z

 

Mechanisms of stretch-mediated skin expansion at single-cell resolution

Aragona M, Sifrim A, Malfait M, Song Y, Van Herck J, Dekoninck S, Gargouri S, Lapouge G, Swedlund B, Dubois C, Baatsen P, Vints K, Han S, Tissir F, Voet T, Simons BD, Blanpain C.

Nature. 2020 Aug;584(7820):268-273. doi: 10.1038/s41586-020-2555-7

 

July


Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP

Crozat E, Tardin C, Salhi M, Rousseau P, Lablaine A, Bertoni T, Holcman D, Sclavi B, Cicuta P, Cornet F.

Nat Commun. 2020 Jul 30;11(1):3796. doi: 10.1038/s41467-020-17606-6

 

Mechanochemical Crosstalk Produces Cell-Intrinsic Patterning of the Cortex to Orient the Mitotic Spindle

Dimitracopoulos A, Srivastava P, Chaigne A, Win Z, Shlomovitz R, Lancaster OM, Le Berre M, Piel M,Franze K, Salbreux G, Baum B.

Curr Biol. 2020 Jul 29:S0960-9822(20)30984-2. doi: 10.1016/j.cub.2020.06.098

 

Single-molecule visualization of DNA G-quadruplex formation in live cells

Di Antonio M, Ponjavic A, Radzevičius A, Ranasinghe RT, Catalano M, Zhang X, Shen J, Needham LM, Lee SF, Klenerman D, Balasubramanian S.

Nat Chem. 2020 Jul 20. doi: 10.1038/s41557-020-0506-4

 

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Doerflinger M, Deng Y, Whitney P, Salvamoser R, Engel S, Kueh AJ, Tai L, Bachem A, Gressier E, Geoghegan ND, Wilcox S, Rogers KL, Garnham AL, Dengler MA, Bader SM, Ebert G, Pearson JS, De Nardo D, Wang N, Yang C, Pereira M, Bryant CE, Strugnell RA, Vince JE, Pellegrini M, Strasser A, Bedoui S, Herold MJ.

Immunity. 2020 Jul 19:S1074-7613(20)30284-3. doi: 10.1016/j.immuni.2020.07.004.

 

Investigating higher-order interactions in single-cell data with scHOT

Ghazanfar S, Lin Y, Su X, Lin DM, Patrick E, Han ZG, Marioni JC, Yang JYH.

Nat Methods. 2020 Jul 13. doi: 10.1038/s41592-020-0885-x.

 

Experimental embryology of gastrulation: pluripotent stem cells as a new model system

Moris N, Martinez Arias A, Steventon B.

Curr Opin Genet Dev. 2020 Jul 11;64:78-83. doi: 10.1016/j.gde.2020.05.031

 

Towards brain-tissue-like biomaterials

Axpe E, Orive G, Franze K, Appel EA.

Nat Commun. 2020 Jul 9;11(1):3423. doi: 10.1038/s41467-020-17245-x

 

The role of single cell mechanical behavior and polarity in driving collective cell migration

Jain S, Cachoux VML, Narayana GHNS, de Beco S, D'Alessandro J, Cellerin V, Chen T, Heuzé ML, Marcq P, Mège RM, Kabla AJ, Lim CT, Ladoux B.

Nat Phys. 2020 Jul;16(7):802-809. doi: 10.1038/s41567-020-0875-z

 

Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma

Jackson ND, Everman JL, Chioccioli M, Feriani L, Goldfarbmuren KC, Sajuthi SP, Rios CL, Powell R, Armstrong M, Gomez J, Michel C, Eng C, Oh SS, Rodriguez-Santana J, Cicuta P, Reisdorph N, Burchard EG, Seibold MA.

Cell Rep. 2020 Jul 7;32(1):107872. doi: 10.1016/j.celrep.2020.107872

 

Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration

Rezk R, Jia BZ, Wendler A, Dimov I, Watts C, Markaki AE, Franze K, Kabla AJ.

Neurooncol Adv. 2020 Jul 3;2(1):vdaa081. doi: 10.1093/noajnl/vdaa081

 

Stem cell lineage survival as a noisy competition for niche access

Corominas-Murtra B, Scheele CLGJ, Kishi K, Ellenbroek SIJ, Simons BD, van Rheenen J, Hannezo E.

Proc Natl Acad Sci U S A. 2020 Jul 1:201921205. doi: 10.1073/pnas.1921205117

 

June


Integrating Chemistry and Mechanics: The Forces Driving Axon Growth

Franze K.

Annu Rev Cell Dev Biol. 2020 Jun 30. doi: 10.1146/annurev-cellbio-100818-125157

 

Microfluidic platform for 3D cell culture with live imaging and clone retrieval

Mulas C, Hodgson AC, Kohler TN, Agley CC, Humphreys P, Kleine-Brüggeney H, Hollfelder F, Smith A, Chalut KJ.

Lab Chip. 2020 Jun 23. doi: 10.1039/d0lc00165a

 

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith MB, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras G.

Nat Cell Biol. 2020 Jun 22. doi: 10.1038/s41556-020-0531-y

 

Axis Specification in Zebrafish Is Robust to Cell Mixing and Reveals a Regulation of Pattern Formation by Morphogenesis

Fulton T, Trivedi V, Attardi A, Anlas K, Dingare C, Arias AM, Steventon B.

Curr Biol. 2020 Jun 12. pii: S0960-9822(20)30735-1. doi: 10.1016/j.cub.2020.05.048.

 

Fractional viscoelastic models for power-law materials

A. BonfantiJ. L. KaplanG. Charras and A. Kabla

Soft Matter. 2020 June 8, doi: 10.1039/D0SM00354A.

 

Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway

Ipseiz N, Pickering RJ, Rosas M, Tyrrell VJ, Davies LC, Orr SJ, Czubala MA, Fathalla D, Robertson AA, Bryant CE, O'Donnell V, Taylor PR.

EMBO J. 2020 Jun 2:e103454. doi: 10.15252/embj.2019103454.

 

Development of Novel Riboswitches for Synthetic Biology in the Green Alga Chlamydomonas

Mehrshahi P, Nguyen GTDT, Gorchs Rovira A, Sayer A, Llavero-Pasquina M, Lim Huei Sin M, Medcalf EJ, Mendoza-Ochoa GI, Scaife MA, Smith AG.

ACS Synth Biol. 2020 Jun 19;9(6):1406-1417. doi: 10.1021/acssynbio.0c00082.

 

Overexpression of chloroplast-targeted ferrochelatase 1 results in a genomes uncoupled chloroplast-to-nucleus retrograde signalling phenotype

Page MT, Garcia-Becerra T, Smith AG, Terry MJ.

Philos Trans R Soc Lond B Biol Sci. 2020 Jun 22;375(1801):20190401. doi: 10.1098/rstb.2019.0401.

 

Kinetic diversity of amyloid oligomers

Dear AJ, Michaels TCT, Meisl G, Klenerman D, Wu S, Perrett S, Linse S, Dobson CM, Knowles TPJ.

Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12087-12094. doi: 10.1073/pnas.1922267117.

 

May


Cortical cell stiffness is independent of substrate mechanics

Rheinlaender J, Dimitracopoulos A, Wallmeyer B, Kronenberg NM, Chalut KJ, Gather MC, Betz T, Charras G, Franze K.

Nat Mater. 2020 May 25. doi: 10.1038/s41563-020-0684-x.

 

Does Gene Expression Noise Play a Functional Role in Plants?

Cortijo S, Locke JCW.

Trends Plant Sci. 2020 May 25. pii: S1360-1385(20)30150-3. doi: 10.1016/j.tplants.2020.04.017.

 

Remote sensing reveals Antarctic green snow algae as important terrestrial carbon sink

Gray A, Krolikowski M, Fretwell P, Convey P, Peck LS, Mendelova M, Smith AG, Davey MP.

Nat Commun. 2020 May 20;11(1):2527. doi: 10.1038/s41467-020-16018-w.

 

Nuclear mechanotransduction in stem cells

Hamouda MS, Labouesse C, Chalut KJ.

Curr Opin Cell Biol. 2020 May 20;64:97-104. doi: 10.1016/j.ceb.2020.05.005.

 

MOFA+: a statistical framework for comprehensive integration of multi-modal single-cell data

Argelaguet R, Arnol D, Bredikhin D, Deloro Y, Velten B, Marioni JC, Stegle O.

Genome Biol. 2020 May 11;21(1):111. doi: 10.1186/s13059-020-02015-1.

 

Hybridization Chain Reaction for Quantitative and Multiplex Imaging of Gene Expression in Amphioxus Embryos and Adult Tissues

Andrews TGR, Gattoni G, Busby L, Schwimmer MA, Benito-Gutiérrez È.

Methods Mol Biol. 2020;2148:179-194. doi: 10.1007/978-1-0716-0623-0_11.

 

Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

Ma CY, Marioni JC, Griffiths GM, Richard AC.

Elife. 2020 May 15;9. pii: e53948. doi: 10.7554/eLife.53948.

 

Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development

Kirkland NJ, Yuen AC, Tozluoglu M, Hui N, Paluch EK, Mao Y.

Curr Biol. 2020 May 12. pii: S0960-9822(20)30555-8. doi: 10.1016/j.cub.2020.04.041

 

Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β 1-42 pathologies

Lautenschläger J, Wagner-Valladolid S, Stephens AD, Fernández-Villegas A, Hockings C, Mishra A, Manton JD, Fantham MJ, Lu M, Rees EJ, Kaminski CF, Kaminski Schierle GS.

J Biol Chem. 2020 May 8. pii: jbc.RA119.011650. doi: 10.1074/jbc.RA119.011650.

 

The role of single-cell mechanical behaviour and polarity in driving collective cell migration

Jain, S., Cachoux, V.M.L., Narayana, G.H.N.S., Beco S, D'Alessandro, J., Cellerin, V., Chen, T., Heuze, M.L., Marcq, P., Mege, RM., Kabla, A.J., Lim, C.T., Ladoux, B.  

Nat. Phys. 2020 May 4. doi.org/10.1038/s41567-020-0875-z.

 

April


Curling of epithelial monolayers reveals coupling between active bending and tissue tension

Fouchard J, Wyatt TPJ, Proag A, Lisica A, Khalilgharibi N, Recho P, Suzanne M, Kabla A, Charras G.

Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9377-9383. doi: 10.1073/pnas.1917838117.

 

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase

Esteras N, Kundel F, Amodeo GF, Pavlov EV, Klenerman D, Abramov AY.

FEBS J. 2020 Apr 27. doi: 10.1111/febs.15340.

 

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, Pavlov EV, Klenerman D, Abramov AY, Gandhi S.

Cell Death Differ. 2020 Apr 27. doi: 10.1038/s41418-020-0542-z.

 

Mechanical Regulation of Neurite Polarization and Growth: A Computational Study

Jakobs MAH, Franze K, Zemel A.

Biophys J. 2020 Apr 21;118(8):1914-1920. doi: 10.1016/j.bpj.2020.02.031.

 

A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division

Stojic L, Lun ATL, Mascalchi P, Ernst C, Redmond AM, Mangei J, Barr AR, Bousgouni V, Bakal C, Marioni JC, Odom DT, Gergely F.

Nat Commun. 2020 Apr 15;11(1):1851. doi: 10.1038/s41467-020-14978-7.

 

Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit

Arter WE, Yusim Y, Peter Q, Taylor CG, Klenerman D, Keyser UF, Knowles TPJ.

ACS Nano. 2020 Apr 15. doi: 10.1021/acsnano.0c00628. 

 

Entrainment of mammalian motile cilia in the brain with hydrodynamic forces

Pellicciotta N, Hamilton E, Kotar J, Faucourt M, Delgehyr N, Spassky N, Cicuta P.

Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8315-8325. doi: 10.1073/pnas.1910065117. 

 

Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase-tRNA pairs

Cervettini D, Tang S, Fried SD, Willis JCW, Funke LFH, Colwell LJ, Chin JW.

Nat Biotechnol. 2020 Apr 13. doi: 10.1038/s41587-020-0479-2.

 

Bionic 3D printed corals

Wangpraseurt D, You S, Azam F, Jacucci G, Gaidarenko O, Hildebrand M, Kühl M, Smith AG, Davey MP, Smith A, Deheyn DD, Chen S, Vignolini S.

Nat Commun. 2020 Apr 9;11(1):1748. doi: 10.1038/s41467-020-15486-4.

 

Robotic microscopy for everyone: the OpenFlexure microscope

Collins JT, Knapper J, Stirling J, Mduda J, Mkindi C, Mayagaya V, Mwakajinga GA, Nyakyi PT, Sanga VL, Carbery D, White L, Dale S, Jieh Lim Z, Baumberg JJ, Cicuta P, McDermott S, Vodenicharski B, Bowman R.

Biomed Opt Express. 2020 Apr 8;11(5):2447-2460. doi: 10.1364/BOE.385729.

 

A direct role for SNX9 in the biogenesis of filopodia

Jarsch IK, Gadsby JR, Nuccitelli A, Mason J, Shimo H, Pilloux L, Marzook B, Mulvey CM, Dobramysl U, Bradshaw CR, Lilley KS, Hayward RD, Vaughan TJ, Dobson CL, Gallop JL.

J Cell Biol. 2020 Apr 6;219(4). pii: e201909178. doi: 10.1083/jcb.201909178.

 

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies

Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, Selkoe DJ, Bartels T

Brain Commun. 2020;2(1):fcaa010. doi: 10.1093/braincomms/fcaa010. 

 

Defining the Design Principles of Skin Epidermis Postnatal Growth

Dekoninck S, Hannezo E, Sifrim A, Miroshnikova YA, Aragona M, Malfait M, Gargouri S, de Neunheuser C, Dubois C, Voet T, Wickström SA, Simons BD, Blanpain C.

Cell. 2020 Apr 5. pii: S0092-8674(20)30277-4. doi: 10.1016/j.cell.2020.03.015.

 

March


The evolutionary dynamics and fitness landscape of clonal hematopoiesis

Watson CJ, Papula AL, Poon GYP, Wong WH, Young AL, Druley TE, Fisher DS, Blundell JR.

Science. 2020 Mar 27;367(6485):1449-1454. doi: 10.1126/science.aay9333.

 

The evolutionary dynamics and fitness landscape of clonal hematopoiesis

Watson CJ, Papula AL, Poon GYP, Wong WH, Young AL, Druley TE, Fisher DS, Blundell JR.

Science. 2020 Mar 27;367(6485):1449-1454. doi: 10.1126/science.aay9333.

 

The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale

Kulenkampff K, Lippert AH, McColl J, Santos AM, Ponjavic A, Jenkins E, Humphrey J, Winkel A, Franze K, Lee SF, Davis SJ, Klenerman D.

Biophys J. 2020 Mar 24;118(6):1261-1269. doi: 10.1016/j.bpj.2020.01.019.

 

Concepts for structured illumination microscopy with extended axial resolution through mirrored illumination

Manton JD, Ströhl F, Fiolka R, Kaminski CF, Rees EJ.

Biomed Opt Express. 2020 Mar 20;11(4):2098-2108. doi: 10.1364/BOE.382398. eCollection 2020 Apr 1.

 

Supersensitive Multifluorophore RNA-FISH for Early Virus Detection and Flow-FISH by Using Click Chemistry

Raddaoui N, Croce S, Geiger F, Borodavka A, Möckl L, Stazzoni S, Viverge B, Bräuchle C, Frischmuth T, Engelke H, Carell T.

Chembiochem. 2020 Mar 18. doi: 10.1002/cbic.202000081. 

 

Contextual Flexibility in Pseudomonas aeruginosa Central Carbon Metabolism during Growth in Single Carbon Sources

Dolan SK, Kohlstedt M, Trigg S, Vallejo Ramirez P, Kaminski CF, Wittmann C, Welch M.

mBio. 2020 Mar 17;11(2). pii: e02684-19. doi: 10.1128/mBio.02684-19.

 

Design of a functionalized metal-organic framework system for enhanced targeted delivery to mitochondria

Haddad S, Abanades Lazaro I, Fantham M, Mishra A, Silvestre-Albero J, Osterrieth JWM, Kaminski Schierle GS, Kaminski CF, Forgan R, Fairen-Jimenez D.

J Am Chem Soc. 2020 Mar 17. doi: 10.1021/jacs.0c00188.

 

Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes

McCarthy DJ, Rostom R, Huang Y, Kunz DJ, Danecek P, Bonder MJ, Hagai T, Lyu R; HipSci Consortium, Wang W, Gaffney DJ, Simons BD, Stegle O, Teichmann SA.

Nat Methods. 2020 Mar 16. doi: 10.1038/s41592-020-0766-3. 

 

The effects of sildenafil on ciliary beat frequency in patients with pulmonary non-tuberculous mycobacteria disease: phase I/II trial

Fowler C, Wu UI, Shaffer R, Smith C, Barnhart L, Bryant C, Olivier K, Holland SM.

BMJ Open Respir Res. 2020 Mar;7(1). pii: e000574. doi: 10.1136/bmjresp-2020-000574.

 

A background correction method to compensate illumination variation in hyperspectral imaging

J. Yoon, A. Grigoroiu and S. E. Bohndiek

 PLoS One. March 14th, 2020, 15(3):e0229502. doi: 10.1371/journal.pone.0229502

 

Mechanical Regulation of Neurite Polarization and Growth: A Computational Study

Jakobs MAH, Franze K, Zemel A.

Biophys J. 2020 Mar 14. pii: S0006-3495(20)30235-6. doi: 10.1016/j.bpj.2020.02.031

 

Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels

Morgan MD, Patin E, Jagla B, Hasan M, Quintana-Murci L, Marioni JC.

PLoS Genet. 2020 Mar 13;16(3):e1008686. doi: 10.1371/journal.pgen.1008686. 

 

Of Cell Shapes and Motion: The Physical Basis of Animal Cell Migration

Bodor DL, Pönisch W, Endres RG, Paluch EK.

Dev Cell. 2020 Mar 9;52(5):550-562. doi: 10.1016/j.devcel.2020.02.013. Review.

 

Voltage-driven annihilation and creation of magnetic vortices in Ni discs

Ghidini M , Mansell R , Pellicelli R , Pesquera D , Nair B , Moya X , Farokhipoor S , Maccherozzi F , Barnes CHW , Cowburn RP , Dhesi SS , Mathur ND.

Nanoscale. 2020 Mar 7;12(9):5652-5657. doi: 10.1039/c9nr08672b

 

Deep learning applied to hyperspectral endoscopy for online spectral classification

A. Grigoroiu, J. Yoon and S. E. Bohndiek

Sci Rep. March 7th, 2020, 10(1):3947. doi: 10.1038/s41598-020-60574-6

 

February


The use of biophysical approaches to understand ciliary beating

Cicuta P.

Biochem Soc Trans. 2020 Feb 28;48(1):221-229. doi: 10.1042/BST20190571. Review.

 

Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery

Madden SK, Itzhaki LS.

Biochim Biophys Acta Proteins Proteom. 2020 Feb 28:140405. doi: 10.1016/j.bbapap.2020.140405. Review.

 

Parkinson's disease-associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages

Levy DR, Udgata A, Tourlomousis P, Symmons MF, Hopkins LJ, Bryant CE, Gay NJ.

J Biol Chem. 2020 Feb 28. pii: jbc.RA119.011842. doi: 10.1074/jbc.RA119.011842.

 

Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids

Georgakopoulos N, Prior N, Angres B, Mastrogiovanni G, Cagan A, Harrison D, Hindley CJ, Arnes-Benito R, Liau SS, Curd A, Ivory N, Simons BD, Martincorena I, Wurst H, Saeb-Parsy K, Huch M.

BMC Dev Biol. 2020 Feb 26;20(1):4. doi: 10.1186/s12861-020-0209-5.

 

Glycation changes molecular organization and charge distribution in type I collagen fibrils

Bansode S, Bashtanova U, Li R, Clark J, Müller KH, Puszkarska A, Goldberga I, Chetwood HH, Reid DG, Colwell LJ, Skepper JN, Shanahan CM, Schitter G, Mesquida P, Duer MJ.

Sci Rep. 2020 Feb 25;10(1):3397. doi: 10.1038/s41598-020-60250-9.

 

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

Meisl G, Knowles TP, Klenerman D

Curr Opin Neurobiol. 2020 Feb 21;61:58-64. doi: 10.1016/j.conb.2020.01.010. 

 

Physiological and Molecular Responses of a Newly Evolved Auxotroph of Chlamydomonas to B12 Deprivation

Bunbury F, Helliwell KE, Mehrshahi P, Davey MP, Salmon DL, Holzer A, Smirnoff N, Smith AG.

Plant Physiol. 2020 Feb 20. pii: pp.01375.2019. doi: 10.1104/pp.19.01375. 

 

Stochastic pulsing of gene expression enables the generation of spatial patterns in Bacillus subtilis biofilms

Nadezhdin E, Murphy N, Dalchau N, Phillips A, Locke JCW.

Nat Commun. 2020 Feb 19;11(1):950. doi: 10.1038/s41467-020-14431-9.

 

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

Hughes C, Choi ML, Yi JH, Kim SC, Drews A, George-Hyslop PS, Bryant C, Gandhi S, Cho K, Klenerman D.

Commun Biol. 2020 Feb 18;3(1):79. doi: 10.1038/s42003-020-0792-9.

 

A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view

Opstad IS, Ströhl F, Fantham M, Hockings C, Vanderpoorten O, van Tartwijk FW, Lin JQ, Tinguely JC, Dullo FT, Kaminski-Schierle GS, Ahluwalia BS, Kaminski CF.

J Biophotonics. 2020 Feb 17:e201960222. doi: 10.1002/jbio.201960222. 

 

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Cuomo ASE, Seaton DD, McCarthy DJ, Martinez I, Bonder MJ, Garcia-Bernardo J, Amatya S, Madrigal P, Isaacson A, Buettner F, Knights A, Natarajan KN; HipSci Consortium, Vallier L, Marioni JC, Chhatriwala M, Stegle O.

Nat Commun. 2020 Feb 10;11(1):810. doi: 10.1038/s41467-020-14457-z.

 

High-throughput, multi-parametric, and correlative fluorescence lifetime imaging

Poudel C, Mela I, Kaminski CF.

Methods Appl Fluoresc. 2020 Feb 20;8(2):024005. doi: 10.1088/2050-6120/ab7364.

 

Cammarota E, Soriani C, Taub R, Morgan F, Sakai J, Veatch SL, Bryant CE, Cicuta P.

J R Soc Interface. 2020 Feb;17(163):20190803. doi: 10.1098/rsif.2019.0803. 

 

Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models

M Gehrung, M Tomaszewski, D McIntyre, J Disselhorst and S Bohndiek 

Photoacoustics February 15th, 2020, 18:100147 doi: 10.1016/j.pacs.2019.100147

 

Eleven grand challenges in single-cell data science

Lähnemann D, Köster J, Szczurek E, McCarthy DJ, Hicks SC, Robinson MD, Vallejos CA, Campbell KR, Beerenwinkel N, Mahfouz A, Pinello L, Skums P, Stamatakis A, Attolini CS, Aparicio S, Baaijens J, Balvert M, Barbanson B, Cappuccio A, Corleone G, Dutilh BE, Florescu M, Guryev V, Holmer R, Jahn K, Lobo TJ, Keizer EM, Khatri I, Kielbasa SM, Korbel JO, Kozlov AM, Kuo TH, Lelieveldt BPF, Mandoiu II, Marioni JC, Marschall T, Mölder F, Niknejad A, Raczkowski L, Reinders M, Ridder J, Saliba AE, Somarakis A, Stegle O, Theis FJ, Yang H, Zelikovsky A, McHardy AC, Raphael BJ, Shah SP, Schönhuth A.

Genome Biol. 2020 Feb 7;21(1):31. doi: 10.1186/s13059-020-1926-6. Review.

 

Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis

Kjell J, Fischer-Sternjak J, Thompson AJ, Friess C, Sticco MJ, Salinas F, Cox J, Martinelli DC, Ninkovic J, Franze K, Schiller HB, Götz M.

Cell Stem Cell. 2020 Feb 6;26(2):277-293.e8. doi: 10.1016/j.stem.2020.01.002.

 

Pre-processing visualization of hyperspectral fluorescent data with Spectrally Encoded Enhanced Representations.

Shi W, Koo DES, Kitano M, Chiang HJ, Trinh LA, Turcatel G, Steventon B, Arnesano C, Warburton D, Fraser SE, Cutrale F.

Nat Commun. 2020 Feb 5;11(1):726. doi: 10.1038/s41467-020-14486-8.

 

Pre-processing visualization of hyperspectral fluorescent data with Spectrally Encoded Enhanced Representations

Shi W, Koo DES, Kitano M, Chiang HJ, Trinh LA, Turcatel G, Steventon B, Arnesano C, Warburton D, Fraser SE, Cutrale F.

Nat Commun. 2020 Feb 5;11(1):726. doi: 10.1038/s41467-020-14486-8.

 

Pressure sensing through Piezo channels controls whether cells migrate with blebs or pseudopods

Srivastava N, Traynor D, Piel M, Kabla AJ, Kay RR.

Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2506-2512. doi: 10.1073/pnas.1905730117.

 

January


F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis

Serres MP, Samwer M, Truong Quang BA, Lavoie G, Perera U, Görlich D, Charras G, Petronczki M, Roux PP, Paluch EK.

Dev Cell. 2020 Jan 27;52(2):210-222.e7. doi: 10.1016/j.devcel.2019.12.011.

 

α-Synuclein strains target distinct brain regions and cell types

Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, Tandon A, Hyman BT, Wille H, Ingelsson M, Klenerman D, Watts JC.

Nat Neurosci. 2020 Jan;23(1):21-31. doi: 10.1038/s41593-019-0541-x.

 

A unified rheological model for cells and cellularised materials

Bonfanti A, Fouchard J, Khalilgharibi N, Charras G, Kabla A

R. Soc. open sci. 2020 Jan 22; 7: 190920.  http://dx.doi.org/10.1098/rsos.190920

 

Twelve tips for engaging with biologists, as told by a physicist

S E Bohndiek

Nature January 12th, 2020, 577(7789):283-284. doi: 10.1038/d41586-019-03961-y

 

Actomyosin controls planarity and folding of epithelia in response to compression

Wyatt TPJ, Fouchard J, Lisica A, Khalilgharibi N, Baum B, Recho P, Kabla AJ, Charras GT.

Nat Mater. 2020 Jan;19(1):109-117. doi: 10.1038/s41563-019-0461-x