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Cambridge Centre for Physical Biology


Research Associate in Biofilm Resilience (Fixed Term)

The aim of the role is to investigate the role of cell heterogeneity as an evolutionary mechanism for biofilm resilience, by developing a library of strains in Bacillus subtilis and E. coli to make perturbations in the gene regulatory network that controls key bacterial phenotype (motility, ECM production) and understand their effects on the spatio-temporal patterns of the corresponding biofilms. After appropriate characterisation, these strains will be used to perform directed evolutionary experiments to understand the rewiring of the network under different environmental conditions. This is an ambitious research program, with a strong interdisciplinary nature, across molecular and synthetic biology, physics and evolutionary biology.

Fusco Lab


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